Approved Use

Repatha® is an injectable prescription medicine used:

  • in adults with cardiovascular disease to reduce the risk of heart Read more attack, stroke, and certain types of heart surgery Read more
  • along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia) to reduce low-density lipoprotein (LDL) or bad cholesterol

Repatha® is the first and only medication of its kind to offer an every-two-week or single monthly injection option. Learn more about each Repatha® dosing option below and talk to your doctor to determine which choice is right for you.

Already taking Repatha®? Click here to watch device demonstration videos.

Every two weeks

SureClick® autoinjector

Single-use prefilled autoinjector*

15-second at-home self-injection with hand-held device

Taken every two weeks

  • Audible click when you start and finish your dose
  • Hidden needle
  • Can inject into your stomach or thigh, or inject into your arm if assisted
  • No need for syringes or vials
Watch demonstration video

Read the full video transcript

Prior to injecting, download and review the SureClick® Autoinjector Instructions for Use.

*140 mg/mL
Injection under the skin

Once a month

Pushtronex® system

Single-use on-body infusor with prefilled cartridge

9-minute at-home self-injection with hands-free device

Taken once a month

  • Lights and sounds when you start and finish your dose
  • Hidden needle
  • Can inject into your stomach or thigh, or inject into your arm if assisted
  • Can do moderate physical activities, such as walking, reaching, or bending, during injection
  • Fits in the palm of your hand
Watch demonstration video

Read the full video transcript

Prior to injecting, download and review the Pushtronex® System Instructions for Use.

420 mg/3.5 mL
Injection under the skin

Prefilled syringe

A single-use prefilled syringe is also available. Watch the injection demonstration video below to learn how to use it.

Watch demonstration video

Prior to injecting, download and review the prefilled syringe Instructions for Use.

Storing and traveling with Repatha®

Store Repatha® in the refrigerator (36°F to 46°F) until you’re ready to use it. Repatha® can also be kept at room temperature (68°F to 77°F) in its original box for up to 30 days. This makes it easier to take your medicine with you when you’re on the go.


Repatha® demonstration videos

Already taking Repatha®? Get an overview on how to take your medication with the SureClick® autoinjector, Pushtronex® system (on-body infusor with prefilled cartridge), or prefilled syringe.

SureClick® autoinjector

Prior to injecting, download and review the SureClick® autoinjector Instructions for Use here.

Pushtronex® system

Prior to injecting, download and review the Pushtronex® system Instructions for Use here.

Prefilled syringe

Prior to injecting, download and review the prefilled syringe Instructions for Use here.


Need injection support?

Watch our injection support video to learn more or contact one of our nurses at 1-844-REPATHA (1-844-737-2842) 7 days a week, 9AM – 11PM EST.

Watch the video

Get needle disposal containers

Recycle your used needles safely, conveniently, and at no cost to you with needle disposal containers that are mailed to your door.

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Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-use prefilled syringes and the inside of the needle caps on the single-use prefilled SureClick® autoinjectors contain dry natural rubber. The single-use Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.

What are the possible side effects of Repatha®?

Repatha® can cause serious side effects including: Repatha® may cause allergic reactions that can be serious. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-use prefilled syringes and the inside of the needle caps on the single-use prefilled SureClick® autoinjectors contain dry natural rubber. The single-use Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.

What are the possible side effects of Repatha®?

Repatha® can cause serious side effects including: Repatha® may cause allergic reactions that can be serious. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.