Approved Use

Repatha® is an injectable prescription medicine used:

  • To reduce the risk of major adverse cardiovascular (CV) events, such as death from cardiovascular disease, heart attack, stroke, certain types of chest pain conditions (unstable angina) requiring hospitalization, or certain types of heart surgery, in adults with cardiovascular disease. READ MORE
  • along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia [HeFH]) to reduce low-density lipoprotein (LDL) or bad cholesterol.
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Dear Repatha Patient,

We want to inform you of an important update to our product portfolio. Amgen® has made the decision to discontinue the Repatha® Pushtronex® System. If you are currently using the Repatha® Pushtronex® system, we kindly advise you to consult with your healthcare provider and transition to one of the other approved Repatha® devices, preferably the SureClick® Autoinjector.

The decision to discontinue the Repatha® Pushtronex® system was made to uphold the high standards Amgen holds for patient experience, focusing on delivering optimal care for patients with cardiovascular disease and hyperlipidemia (high bad cholesterol).

Amgen® is committed to supporting patients as they transition from the Pushtronex® system.


Important Next Steps for You and Your Doctor

If you are currently using the Repatha® Pushtronex® system, we kindly advise you to consult with your healthcare provider and transition to one of the other approved Repatha® devices, preferably the SureClick® Autoinjector. The SureClick® Autoinjector is the #1 prescribed Repatha® device. It has less steps and shorter administration duration than the Pushtronex® system.


Pushtronex® System- Discontinued

pushtronex

The Repatha® Pushtronex®
system has been discontinued.

420mg/3.5mL single-dose on-body infusor with prefilled cartridge
NDC: 72511-0770-01

SureClick® Autoinjector- Active and Available

Autoinjector

Talk to your Doctor about transitioning to the SureClick® autoinjector.
The #1 prescribed Repatha® device.

140 mg/mL single-dose
prefilled autoinjector
NDC: 72511-0760-02

Patients with a Latex Allergy

A limited supply of Pushtronex® system is available for patients with a latex allergy through certain wholesalers. If you have a latex allergy and are unable to fill your Pushtronex® system prescription, you are encouraged to use the new prefilled syringe not made with natural rubber latex until the SureClick® that is not made with natural rubber latex is available (limited supply April 2025 full supply expected by summer 2025).



If you’re currently using the Repatha® Pushtronex® system – Next Steps & Support Available to You:

It is important to note there are no concerns about the drug product quality, efficacy, or patient safety of the Repatha devices.

Before your next scheduled dose of Repatha®, please contact your doctor to request a new prescription for Repatha® with an alternative device, preferably the SureClick® Autoinjector administered every two weeks.

For any additional questions, Amgen is committed to supporting existing Pushtronex® patients’ transition and has several dedicated services in place. Resources include:

  • Dedicated transition support line through Amgen® SupportPlus at 1-844-REPATHA (1-844-737-2842), option 2. Hours: Monday-Friday 8:00 am - 8:00 pm ET
  • Amgen Nurse Partner Support*
*Amgen Nurse Partners are only available to patients that are prescribed certain Amgen products. They are not part of your treatment team and do not provide medical advice, nursing, or case management services. Amgen Nurse Partners will not inject patients with Amgen medications. Patients should always consult their healthcare provider regarding medical decisions or treatment concerns.


Other Questions?

If you have any additional questions about Repatha®, or need support with your injection, please call your healthcare provider.

To review more details on the Pushtronex® system update, please kindly refer to the Frequently Asked Questions (FAQs) for Patients provided here.


Sincerely,
Amgen Inc.

Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Repatha® is available as prefilled single-dose SureClick® autoinjectors and prefilled single-dose syringes that either contain dry natural rubber (a derivative of latex) in the needle cover or are not made with natural rubber latex. The carton and "Instructions for Use" will state if your prefilled single-dose SureClick® autoinjector or prefilled single-dose syringe contains dry natural rubber. The single-dose Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.

What are the possible side effects of Repatha®?

Repatha® can cause serious side effects including serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes) and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

APPROVED USE

What is Repatha®?

Repatha® is an injectable prescription medicine used:

  • To reduce the risk of major adverse cardiovascular (CV) events, such as death from cardiovascular disease, heart attack, stroke, certain types of chest pain conditions (unstable angina) requiring hospitalization, or certain types of heart surgery, in adults with cardiovascular disease.
  • along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia [HeFH]) to reduce low density lipoprotein (LDL) or bad cholesterol.

Please see full Prescribing Information, including Patient Product Information.

Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including
if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Repatha® is available as prefilled single-dose SureClick® autoinjectors and prefilled single-