Approved Use

Repatha® is an injectable prescription medicine used:

  • in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of heart surgery. READ MORE
  • along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia [HeFH]) to reduce low-density lipoprotein (LDL) or bad cholesterol.
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Dear Repatha Patient,

We want to inform you of an important update to our product portfolio. Amgen® has made the decision to discontinue the Repatha Pushtronex® System. If you are currently using the Repatha® Pushtronex device, we kindly advise you to consult with your healthcare provider and transition to one of the other approved Repatha® devices, preferably the SureClick® Autoinjector.*

The decision to discontinue the Repatha® Pushtronex device was made to uphold the high standards Amgen holds for patient experience, focusing on delivering optimal care for patients with cardiovascular disease and hyperlipidemia (high bad cholesterol).

We plan to discontinue the Repatha® Pushtronex® on June 30th, 2024 and are committed to support patients as they transition.


Important Next Steps for You and Your Doctor

Prior to this date, if you are currently using the Repatha® Pushtronex® device, we kindly advise you to consult with your healthcare provider and transition to one of the other approved Repatha® devices, preferably the SureClick® Autoinjector.* The SureClick Autoinjector is the #1 prescribed Repatha® device. It has less steps and shorter administration duration than the Pushtronex® device.

Pushtronex® System- Discontinued

pushtronex

The Repatha® Pushtronex® system discontinued, effective June 30th, 2024

420mg/3.5mL single-dose on-body infusor with prefilled cartridge
NDC: 72511-0770-01

SureClick® Autoinjector- Active and Available

Autoinjector

Talk to your Doctor about transitioning to the SureClick®.
The #1 prescribed Repatha® device.

140 mg/mL single-dose prefilled autoinjector
NDC: 72511-0760-02

If you’re currently using the Repatha® Pushtronex® system – Next Steps & Support Available to You:

It is important to note there are no concerns about the drug product quality, efficacy, or patient safety of the Repatha devices.

Before your next scheduled dose of Repatha®, please contact your doctor to request a new prescription for Repatha® with an alternative device, preferably the SureClick® Autoinjector administered every two weeks.

For any additional questions, Amgen is committed to supporting existing Pushtronex® patients’ transition and has several dedicated services in place. Resources include:

  • Dedicated transition support line through Amgen® SupportPlus at 1-844-REPATHA (1-844-737-2842), option 2. Hours: Monday-Friday 8:00 am - 8:00 pm ET
  • Amgen Nurse Partner Support, including supplemental injection support.

Other Questions?

If you have any additional questions about Repatha®, or need support with your injection, please call your healthcare provider.

To review more details on the Pushtronex® update, please kindly refer to the Frequently Asked Questions (FAQs) for Patients provided here.

For a Spanish translation of this update, please visit Repathaespanol.com/pushtronexsystemupdate.

Sincerely,
Amgen Inc.

*For patients with a latex allergy please consult with your healthcare provider on what is the right approach for you.

Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-dose prefilled syringes and the inside of the needle caps on the single-dose prefilled SureClick® autoinjectors contain dry natural rubber. The single-dose Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.

What are the possible side effects of Repatha®?

Repatha® can cause serious side effects including serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes) and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

APPROVED USE

What is Repatha®?

Repatha® is an injectable prescription medicine used:

  • in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of heart surgery.
  • along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia [HeFH]) to reduce low density lipoprotein (LDL) or bad cholesterol.

Please see full Prescribing Information.

Important Safety Information

Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including
if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. The needle covers on the single-dose prefilled syringes and the inside of the needle caps on the single-dose prefilled SureClick® autoinjectors contain dry natural rubber. The single-dose Pushtronex®